A new drug-safety alert has been issued in Manchester after several ketamine samples were confirmed to contain medetomidine, a highly potent veterinary sedative. The report comes directly from Mandrake Lab, who first published the findings through their official channel
The warning has also been supported by the Greater Manchester Drugs Early Warning System, which coordinates public-health communication across the region
Medetomidine is significantly stronger than xylazine and can cause heavy sedation, slowed breathing, loss of consciousness and delayed reactions even in very small amounts. Harm-reduction teams in Manchester are urging anyone who uses ketamine to test their substances with medetomidine-specific strips, begin with very small doses and avoid redosing for at least one hour, as contaminated samples can take longer for their full effects to appear. If someone becomes unresponsive, it is essential to keep their airway clear, place them in the recovery position and call emergency services immediately.
This alert highlights the growing unpredictability of the current illicit drug market and the importance of accurate, transparent safety information within nightlife culture. The findings reported by Mandrake Lab and the Greater Manchester Drugs Early Warning System offer essential guidance to protect the community and reduce risks during nights out, festivals and social settings.
At Mr. Afterparty we share this news to support the health and safety of our global community. Clear information saves lives, and staying informed is one of the strongest harm-reduction tools we have.
What You Need to Know About Medetomidine
Medetomidine is an animal tranquilizer and alpha-2 adrenergic agonist commonly used in veterinary medicine. When mixed with or mistaken for ketamine, it poses serious health risks to drug users. The substance can cause dangerous side effects including respiratory depression, loss of consciousness, and cardiovascular complications. Understanding these risks is crucial for harm reduction and emergency response.
Drug Testing and Harm Reduction
If you or someone you know uses ketamine, testing your supply with medetomidine-specific reagent tests is essential. Multiple test kits can help identify contaminants. Always start with small doses, never use alone, and have naloxone available. Keep emergency services numbers programmed in your phone. The Greater Manchester Drugs Early Warning System and local harm reduction services provide support and resources.
Why This Alert Matters
This contamination issue underscores the dangers of unregulated drug markets. Harm reduction services, drug checking programs, and public health communication are essential tools for minimizing overdose deaths and other drug-related harms. Community awareness and accessible testing resources can save lives. Stay informed through reliable sources and support harm reduction initiatives in your area.
